Unitary Symmetry of Combinatorial Molecules and Mixtures. Part 1: The New Pharmacology as a Valuable Tool in Drug Discovery

Atoms and molecules are the classical discrete combinatorial objects. Thus combinatorial operation can be applied to the objects in their steady (equilibrium) state, and when the reagents considered in successive stationary states at each time point during the entire reaction. Thus combinatorial operations imply a stationary version combinable initial set of elements both in the presence of an immutable "core", and so in its absence. Combinatorial operation in kinetic variant are sequential combination of reagents parts which are practically in the same condition of the different initial objects (without considering the critical temperature and pressure). Sets of molecules and radicals, appears as a result of combinations of ligands will be called combinatorial molecules. In these cases, the discreteness is given by discrete nature of the ligands. But discrete objects can be created artificially, representing different pure substances in the form of the set of identical fractions. By mixing such substances in various proportions can be obtained the combinatorial mixture of substances. The main feature of combinatorial objects is their natural alignment in cross-homologous series. This property of the combinatorial objects allows to obtain self-consistent, most reliable values of the physical (chemical, biological, ...) parameter. The main feature of chemical entities is the existence of the interactions' hierarchy between nuclei and electrons. between the internal and the valence electrons, between the electron cloud of constant core and the electron cloud of the